[醫療] 醫界發現兩種神經蛋白有利追蹤頭痛

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[Medical] Two Kinds of Neuroproteins That Help Track Cephalalgia Have Been Identified
July 27, 2009 08:48PM

發表文章數: 619
[Medical] Two Kinds of Neuroproteins That Help Track Cephalalgia Have Been Identified (Chinese Version)

China Times E-paper (2009/07/26) Migraine and cluster headache are two of the most commonplace headache classifications. Their diagnosis depends on patient's first personal report presently, but in this way the precise location or status of pain is difficult to specify. NTU and Taipei Veterans General Hospital find in a new study that it can take phlebotomy test alone targeting two neuroproteins in the brain to specify the pain grade, bringing great enhancement to follow-up treatment. Along with the finding, it is also discovered that one of the headache-related neuroprotein, Orexin A, increases appetite, which explains the phenomenon that people with higher BMI (body mass index) suffer from headache more frequently.

According to Chair of Department of Neurology, Taipei Veterans General Hospital, Shuu-Jiun WANG, the activation of trigeminal vascular system in the brain is commonly regarded as the pathogenic mechanism for sick headache and cluster headache. Stick to this premise, the research team hypothesizes that the system activator Nociceptin and the system inhibitor Orexin A these two kinds of neuroproteins are related to the pain degree of migraine and cluster headache. The experiments show that the concentration of Nociceptin in the adult headache group is far lower than the control group, and the children groups perform little specific significance; on the contrary, Orexin A concentration in both the adult and the children headache groups is higher than the control groups, though the difference in the children groups is not strong as well, which is believed to be related with the immature pain mechanism of the children.

S.-J. WANG says, both the conventional inferences and animal experiments support that Nociceptin strengthens the pain response and Orexin A prohibits the pain. But the present study results in an opposite outcome, suggesting that Nociceptin and Orexin A together “balance” the brain. The patient, for instance, whose headache intensifies needs less Nociceptin and more Orexin A.


Reference:
China Times E-paper 2009/07/26


[醫療] 醫界發現兩種神經蛋白有利追蹤頭痛
[醫療] 醫界發現兩種神經蛋白有利追蹤頭痛 （英文版）

《中時電子報》（2009/07/26） 偏頭痛及叢發性頭痛是兩種最常見的頭痛，目前臨床診斷都靠患者主觀描述，但患者確切的疼痛位置總無法清楚指出。臺大與台北榮總最新研究發現，只要透過抽血檢測腦內兩種神經蛋白質，即可瞭解患者頭痛程度，對追蹤治療效果有幫助。該研究還發現，由於下視丘素會增加食慾，故ＢＭＩ（身體質量指數）愈高者，愈容易頭痛。

北榮神經內科主任王署君表示，腦內三叉神經血管系統活化與否，是醫界公認的偏頭痛與叢發性頭痛致病機轉，故研究團隊推測，可活化該系統的致痛素（Nociceptin），以及抑制該系統的下視丘素（Orexin A）兩種神經蛋白質，應與偏頭痛與叢發性頭痛的程度有關。經由實驗發現，致痛素在成人頭痛組的濃度竟遠低於對照組，兒童組的差異性則不具統計意義；至於下視丘素則在成人與兒童組中的濃度，均高於對照組，但兒童組的差異程度也不明顯，推測應與兒童的疼痛機制尚未發展完全有關。

王署君說，一般推論及動物實驗都顯示，致痛素會增加動物疼痛反應，下視丘素則有止痛效果，但此次研究結果卻正好相反，顯示致痛素與下視丘素在人類大腦中可能扮演「平衡」的角色，亦即當患者頭痛程度愈強烈時，大腦就愈不需要分泌致痛素，相對下視丘素濃度就愈高。


資訊來源：
中時電子報 2009/07/26